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Ketogenic diet in cancer prevention and therapy: molecular targets and therapeutic opportunities

Recently, a metastable activation site on GPX4 has been identified, leading to the discovery of several GPX4 activators

One approach is to position the GST tag at the N-terminus or C-terminus of the target protein, depending on which end is less likely to affect the protein's function

We first examined whether MIEAP, a molecule involved in noncanonical mitophagy, and ATG5, a component of autophagic machinery and involved in canonical mitophagy, are tumor suppressors in thyroid carcinogenesis using genetically engineered mice and found that thyroid cancer development was accelerated in Braf thyrV600E ,Atg5 thyrKO/KO and Braf thyrV600E ,Mieap KO/KO mice compared with Braf thyrV600E mice

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